| 摘要 |
The invention concerns a novel beta-secretase, a method of partially purifying this novel beta-secretase, and its use in assays to screen for potential drug candidates against Alzheimer's disease and other neurological diseases. The novel beta-secretase has an estimated molecular weight of about 32-39 kDa or 22-26 kDa in HEK293 cell membrane extracts and human brain samples, respectively, as calculated from radiation inactivation analysis, and has a pH optimum at about pH 6.5-7.0.
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