| 发明名称 |
1-OR 3-THIA-BENZONAPHTOAZULENES AS INHIBITORS OF TUMOR NECROSIS FACTOR PRODUCTION AND INTERMEDIATES FOR THE PREPARATION THEREOF |
| 摘要 |
<p>The present invention relates to 1- or 3-thiabenzonaphthoazulene derivatives to their pharmacologically acceptable salts and solvates, to processes and intermediates for the preparation thereof as well as to their antiinflammatory effects, especially to the inhibition of tumour necrosis factor-alpha (TNF-alpha) production and the inhibition of interleukin-1 (IL-1) production as well as to their analgetic action.</p> |
| 申请公布号 |
YU88104(A) |
申请公布日期 |
2006.08.17 |
| 申请号 |
YU2004P000881 |
申请日期 |
2003.04.09 |
| 申请人 |
PLIVA-ISTRAZIVACKI INSTITUT D.O.O. |
发明人 |
MERCEP, MLADEN;MESIC, MILAN;PESIC, DIJANA;OZIMEC, LVANA;TROJKO, RUDOLF |
| 分类号 |
C07D495/04;A61K31/38;A61K31/381;A61K31/4025;A61K31/4535;A61K31/5377;A61P1/04;A61P9/00;A61P11/00;A61P11/06;A61P13/12;A61P17/00;A61P17/06;A61P19/02;A61P19/06;A61P25/00;A61P29/00;A61P31/04;A61P31/12;A61P31/18;A61P37/02;A61P37/08;A61P43/00;C07D333/80;C07D337/16;C07D413/02 |
主分类号 |
C07D495/04 |
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