发明名称 |
VERFAHREN ZUR HERSTELLUNG VON ZUSAMMENSETZUNGEN MIT GERINGER SALZKONZENTRATION |
摘要 |
Method for desalting an aqueous liquid containing a charged substance comprising the steps of: (i) contacting liquid (I) with an ion-exchanger (1) under conditions permitting binding between ion-exchanger and substance, said ion-exchanger comprising a base matrix carrying an ion-exchange ligand (Ligand 1) with the opposite charge compared to the substance, (ii) desorbing said substance from said ion-exchanger by the use of a liquid (liquid (II)). Wherein: (A) ion-exchanger (1) is an ion-exchanger: (a) that can bind the substance in an aqueous reference liquid at ionic strength corresponding to 0.1 M NaCl, preferably 0.25 M NaCl; and (b) permits a breakthrough capacity at the pH provided by liquid (I) which is more than 2 mg/ml of gel, at a breakthrough of 10% and linear flow velocity of 300 cm/h; and (B) in step (ii) the pH of liquid (11) is adjusted to a pH value where the charge difference between the substance, the ligand and/or the ion-exchanger is lowered. |
申请公布号 |
AT334746(T) |
申请公布日期 |
2006.08.15 |
申请号 |
AT20010985906T |
申请日期 |
2001.12.19 |
申请人 |
GE HEALTHCARE BIO-SCIENCES AB |
发明人 |
BELEW, MAKONNEN;JOHANSSON, BO-LENNART;MALOISEL, JEAN-LUC |
分类号 |
A23L33/00;A61K38/00;A61K39/395;A61P7/00;A61P37/00;B01J39/04;B01J39/26;B01J41/04;B01J41/20;B01J47/14;B01J49/00;C02F1/42;C07K1/18 |
主分类号 |
A23L33/00 |
代理机构 |
|
代理人 |
|
主权项 |
|
地址 |
|