11,11-DIMETHYL-1-OXO-1,2,10,11-TETRAHYDROBENZO[h]PYRROLO-[2,1-a]-ISOQUINOLINE-2-SPIRO-2-(1-ARYL-3-AROYL-4-HYDROXY-5-OXO-2,5-DIHYDROPYRROLES) ELICITING ANTIBACTERIAL ACTIVITY AGAINST GRAM-POSITIVE MICROFLORA

摘要

FIELD: organic chemistry, chemical technology. ^ SUBSTANCE: invention relates to novel 11,11-dimethyl-1-oxo-1,2,10,11-tetrahydrobenzo[h]pyrrolo[2,1-a]-isoquinoline-2-spiro-2-(1-aryl-3-aroyl-4-hydroxy-5-oxo-2,5-dihydropyrroles) of the formulae (Ia-d): wherein Ar means Ph (Ia, b), C6H4OEt-4 (Ic), C6H4Cl-4 (Id); Ar' means C6H4Me-4 (Ia, c, d), C6H4Cl-4 (Ib) that elicit antibacterial activity against gram-positive microflora. Compounds of the formula (I) are prepared by interaction of 1-aryl-4-aroyl-5-methoxycarbonyl-2,3-dihydro-2,3-pyrrolidones with 1,3,3-trimethyl-3,4-dihydrobenzo[f]isoquinoline in absolute benzene medium at boiling for 2 min followed by isolation of end products by the known procedures. Synthesized compounds are not toxic practically. ^ EFFECT: improved preparing method, valuable biological properties of compounds. ^ 1 tbl, 1 sch, 2 ex