SUBSTITUTED N-ARYL-9-OXO-9H-FLUORENE-1-CARBOXAMIDES AND ANALOGS AS ACTIVATOR OF CASPASES AND INDUCERS OF APOPTOSIS
摘要
The present invention is directed to substituted N-aryl-9-oxo-9H-fluorene-1-carboxamides and analogs thereof, represented by the general Formula I: (I) wherein R<SUB>1</SUB>-R<SUB>8</SUB>, X and Ar are defined herein. The present invention also relates to the discovery that compounds having Formula I are activators of caspases and inducers of apoptosis. Therefore, the activators of caspases and inducers of apoptosis of this invention can be used to induce cell death in a variety of clinical conditions in which uncontrolled growth and spread of abnormal cells occurs.
申请公布号
WO2006039356(A3)
申请公布日期
2006.08.10
申请号
WO2005US34890
申请日期
2005.09.29
申请人
CYTOVIA, INC.;KEMNITZER, WILLIAM, E.;CAI, SUI XIONG;DREWE, JOHN, A.;SIRISOMA, NILANTHA, SUDATH
发明人
KEMNITZER, WILLIAM, E.;CAI, SUI XIONG;DREWE, JOHN, A.;SIRISOMA, NILANTHA, SUDATH