METHODS OF IDENTIFYING MODULATORS OF BROMODOMAINS

摘要

The present invention features compounds of the following general formula (I) wherein R<SUP>1</SUP> is selected from the group consisting of hydrogen, lower alkyl, aryl, aralkyl; substituted aralkyl, heteroaryl; substituted heteroaryl, phenyl, SO<SUB>2</SUB>, NH<SUB>2</SUB>, NO<SUB>2</SUB>, SO<SUB>2</SUB>, CH<SUB>2</SUB>, CH<SUB>2</SUB>CH<SUB>3</SUB>, OCH<SUB>3</SUB>, OCOCH<SUB>3</SUB>, CH<SUB>2</SUB>COCH<SUB>3</SUB>, and OH, CN and halogen; R<SUP>2</SUP> is selected from the group consisting of hydrogen; lower alkyl, aryl, phenyl, aralkyl; substituted aralkyl, heteroaryl; substituted heteroaryl, SO<SUB>2</SUB> NH<SUB>2</SUB>NH<SUB>3</SUB>