| 摘要 |
PROBLEM TO BE SOLVED: To provide a method for effectively raising the expression of GPRC5A gene. SOLUTION: The method for raising the expression of the GPRC5A gene with a substance raising the concentration of cAMP (cyclic adenosine monophosphate) in a cell is disclosed. A substance inhibiting a PDE (phosphodiesterase), adenosine triphosphate and a substance increasing the amount thereof, a substance activating adenyl cyclase, a substance stimulating a cell membrane receptor conjugating with a Gαs protein and a substance suppressing the cell membrane receptor conjugating with a Gαi protein can be used as the substance raising the concentration of the cAMP. An antibody having actions similar thereto, siRNA (small interfering RNA), an adaptamer and gene transfer can be used. A method for raising the expression of the GPR5C gene by using the substance raising the cAMP concentration and retinoic acid or a retinoic acid derivative in combination is disclosed. The raising of the expression of the GPRC5A is useful for biological research related to the development of medicines, etc., and treatment of diseases. COPYRIGHT: (C)2006,JPO&NCIPI
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