发明名称 |
Method of preparing ligands for hydrophobic interaction chromatography |
摘要 |
The invention is a method of preparing multimodal ligands for hydrophobic interaction chromatography (HIC), which comprises providing a cyclic scaffold comprising a thiol, an amine and a carbonyl group; derivatisation of the nitrogen with a reagent to introduce a primary interaction; and aminolysis of the resulting derivative, whereby a secondary interaction is introduced next to the carbonyl; wherein at least one of the primary interaction and the secondary interaction comprises a hydrophobic group and wherein non of said interactions comprises charged groups, i.e. ion exchange ligands. The invention also encompasses a separation medium comprising such multimodal ligands immobilised to a base matrix.
|
申请公布号 |
US2006175258(A1) |
申请公布日期 |
2006.08.10 |
申请号 |
US20040547570 |
申请日期 |
2004.03.05 |
申请人 |
JOHANSSON BO-LENNART;MALOISEL JEAN-LUC;THEVENIN NICOLAS |
发明人 |
JOHANSSON BO-LENNART;MALOISEL JEAN-LUC;THEVENIN NICOLAS |
分类号 |
C07F5/04;B01D15/08;B01D15/32;B01J20/286 |
主分类号 |
C07F5/04 |
代理机构 |
|
代理人 |
|
主权项 |
|
地址 |
|