| 摘要 |
The invention relates to a method and a device for manipulating samples, in particular tissue samples, comprising at least one needle ( 2 ) for punching holes ( 34 ) in sample carriers ( 4 ) and at least one further needle ( 3 ) for punching samples out of preparations ( 5 ), wherein a device for detecting the position of the surface of the sample carriers ( 4 ) is provided. According to the invention, the device for detecting the position of the surface of the sample carriers ( 4 ) or preparations ( 5 ) is formed by suction lines ( 9 ) opening into the needles ( 2, 3 ), whereby the suction lines ( 9 ) are connected with a unit ( 11 ) for detecting negative pressure so that the approach of the needles ( 2, 3 ) to the surface of the sample carriers ( 4 ) or the preparations ( 5 ) is detectable by the resulting negative pressure and that a drive unit ( 7 ) is provided for displacing the needles ( 2, 3 ) relative to the sample carrier ( 4 ) or preparation ( 5 ) from the detected position of the surface to a predefined punching depth (D).
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