MUCIN RELATING TO EPIGLYCANIN

摘要

[PROBLEMS] To declare for the first time the isolation of a mucin-like glycoprotein relating to epiglycanin and a nucleic acid encoding this protein. To clarify for the first time the existence of a human homolog of the mouse protein as described above. [MEANS FOR SOLVING PROBLEMS] It is intended to provide a mucin-like protein having an amino acid sequence represented by the general formula: A-Bn-C-D-E (wherein A represents an N-terminal region containing a signal sequence; Bn represents a tandem repeat region with the repetition of an amino acid sequence (B) which is rich in serine/threonine providing O-glycosylation sites and consists of from about 11 to about 15 amino acid residues (n=20 to 150); C represents a potential enzyme-cleavage site-containing region; D represents a transmembrane region showing a high homology between mouse and humans; and E represents an intraplasmic region).