Preparing aldesleukin for pharmaceutical use

摘要

A process for preparing aldesleukin for pharmaceutical use, comprising the steps of: (a) adding SDS to a composition comprising aldesleukin, to give a high final SDS concentration; (b) reducing SDS levels to give a composition with a low SDS concentration. Addition and then partial removal of SDS gives microaggregates of aldesleukin and SDS that are suitable for pharmaceutical use.