发明名称 |
RECOMBINANT HUMAN FACTOR VIII DERIVATIVE |
摘要 |
A DNA sequence coding for a biologically active recombinant human factor VII I derivative, comprising a first DNA segment coding for the 90 kDa chain of human factor VIII and a second DNA segment coding for the 80 kDa chain of human factor VIII; said segments being interconnected by a linker DNA segment coding for a linker peptide of 4 to about 100 amino acid residues of the B domain of human factor VIII, at least 4 of said amino acid residues originating from the C terminal of said domain; recombinant expression vector comprising such DNA sequence; host cel ls of animal origin transformed with such recombinant expression vector; a process for the manufacture of recombinant human factor VIII derivative; and human factor VIII derivative containing the heavy chain and the light chain. linked by metal ion bond.</S DOAB>
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申请公布号 |
CA2071875(C) |
申请公布日期 |
2006.08.08 |
申请号 |
CA19902071875 |
申请日期 |
1990.12.06 |
申请人 |
KABI PHARMACIA AKTIEBOLAG |
发明人 |
ALMSTEDT, ANNELIE B.;LARSSON, KERSTIN;LIND, PETER;SPIRA, JACK;SYDOW-BAECKMAN, MONA;HELLSTROM, EVA MARIA;SANDBERG, HELENA INGA |
分类号 |
A61K38/43;C12N15/62;A61K38/00;A61P7/04;C07K14/00;C07K14/745;C07K14/755;C07K19/00;C12N5/10;C12N9/64;C12N15/09;C12N15/12;C12N15/57;C12N15/85;C12P21/02;C12R1/91 |
主分类号 |
A61K38/43 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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