Peptide interacting with anti-apoptotic members of Bcl-2 protein family useful for the treatment of cancers,

摘要

A peptide interacting with members of the anti-apoptotic Bcl-2 protein family comprising a fully defined 24 amino acid sequence (SEQ ID NO. 1-6) given in the specification, or their functional variants, is new. Independent claims are included for: (1) nucleic acid sequences encoding the peptide; (2) a recombinant vector comprising the nucleic acid sequence; (3) a host cell comprising the vector; (4) a pharmaceutical composition comprising the peptide; and (5) identifying (M1) modulators of the interaction of the peptide and an anti-apoptotic Bcl-2 family member comprising: (a) contacting the peptide with an anti-apoptotic Bcl-2 family member; (b) adding the test compound; and (c) measuring the activity of the test compound which modulates interaction between the peptide and anti-apoptotic Bcl-2 family member and comparing it to a measurment taken in the absence of the test compound. ACTIVITY : Cytostatic; Apoptotic. No biological data given. MECHANISM OF ACTION : None given.