发明名称 |
Screening molecules with anti-prion activity: kits, methods and screened molecules |
摘要 |
The invention concerns screening molecules with anti-prion activity. More particularly, it concerns kits for screening molecules with anti-prion activity characterized in that they comprise in combination a [PSI+], phenotype yeast, an antibiogram and an agent for purifying prions at sub-efficient doses, said yeast including the adel-14 allele of the ADE1 gene and an inactivated ERG6 gene, the screening methods, and a family of molecules with anti-prion activity isolated by the inventive screen. The invention is applicable to anti-prion agents for producing medicines in particular for treating neurodegenerative diseases involving protein aggregates.
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申请公布号 |
US2006172337(A1) |
申请公布日期 |
2006.08.03 |
申请号 |
US20050531594 |
申请日期 |
2005.11.20 |
申请人 |
BLONDEL MARC;CULLIN CHRISTOPHE;VIERFOND JEAN M;BACH STEPHENE;TALAREK NICOLAS;METTEY YVETTE |
发明人 |
BLONDEL MARC;CULLIN CHRISTOPHE;VIERFOND JEAN M.;BACH STEPHENE;TALAREK NICOLAS;METTEY YVETTE |
分类号 |
G01N33/53;A61P25/28;C12N1/19;C12Q1/02;C12Q1/18 |
主分类号 |
G01N33/53 |
代理机构 |
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地址 |
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