CHONDROCYTE-BASED IMPLANT FOR THE DELIVERY OF THERAPEUTIC AGENTS

摘要

The present invention relates in general to chondrocyte based explants and implants comprising genetically engineered chondrocytes and in particular, to the delivery of peptides, proteins and RNAi molecules to a mamalian subject using a genetically modified chondrocyte-based mass. In one embodiment the genetically modified chondrocyte-based mass is provided as a chondrocyte pellet.