摘要 |
A composition for solid pharmaceutical preparations, essentially consisting of a cyanopyrrolidine derivative represented by the following general formula (1) or a pharmaceutically acceptable salt thereof, and at least one stabilizing ingredient selected from the group consisting of sugars and sugar alcohols, [Formula 1] [wherein R1 represents, for example, a halogen atom or a hydroxyl group, R<SUP>3</SUP> and R<SUP>4</SUP> may be the same or different, each represents, for example, a hydrogen atom or a halogen atom, X represents an oxygen atom or a sulfur atom, Y represents, for example, a group represented by -CR<SUP>5</SUP>R<SUP>6</SUP>- (wherein R<SUP>5</SUP> and R<SUP>6</SUP> may be the same or different, each represents, for example, a hydrogen atom or a halogen atom), W represents, for example, a hydrogen atom or an acyl group derived from naturally occurring amino acids, and Z represents, for example, a hydrogen atom or an alkyl group of 1 to 10 carbon atoms which may be substituted with one or more substituents selected from the group consisting of a halogen atom, a hydroxyl group, a hydroxylalkyl group of 1 to 5 carbon atoms, a carboxyl group, a mercapto group and the like]. |