Homopiperazine derivative, pharmaceutical composition containing this derivative and using of it

摘要

A homopiperazine derivative of formula (II) any of its enantiomers or any mixture of enantiomers, isotopes thereof or a pharmaceutically acceptable salt thereof; wherein R represents hydrogen, C1-C8alkyl, or benzyl; and R1 represents aminophenyl; nitrophenyl; hydroxyphenyl; alkoxyphenyl or a 3-pyridyl or a pyrazinyl group, which heterocyclic group may be substituted one or more times with substituents selected from the group consisting of C2-C6alkynyl, C1-C7alkoxy, C3-C7cycloalkoxy, C1-C7alkoxyC1-C7alkoxy, C2-C6alkenoxy, halogen, -CF3, trifluoromethansulfonyloxy and -CONR2R3, wherein R2 and R3 are hydrogen; and phenyl, which is optionally substituted with nitro, thiophenyl, thiobenzyl, pyrrolidinyl, pyridyl, pyrrolyl, or indolyl; or R1 represents a 4-isoquinolinyl group. The compounds of formula (II) are useful as nicotinic ACh receptor ligands.