| 摘要 |
A family of imidazole compounds useful for inhibiting the activity of prenyl transferases. The compounds are covered by formula (I): wherein X is (CHR<SUP>11</SUP>)<SUB>n3</SUB>(CH<SUB>2</SUB>)<SUB>n4</SUB>Z(CH<SUB>2</SUB>)<SUB>n5 </SUB>where Z is O, N(R<SUP>12</SUP>), S, or a bond; Y is CO, CH<SUB>2</SUB>, CS, or a bond; R<SUP>1 </SUP>is A, B, C, D, E, F, G, H, I, J or N(R<SUP>24</SUP>R<SUP>25</SUP>); and the remaining substituents are as defined in the disclosure
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