Stereospecific enrichment of heterocyclic enantiomers

摘要

The present invention describes methods for the stereoselective synthesis of heterocyclic enantiomers. The methods of the present invention incorporate the stereo-preferred oxidation of quinolone thiomethyl intermediates by optically active camphor based oxaziridines to provide R(+) or S(-) quinolone methylsulfinyl derivatives.