发明名称 |
High affinity fusion proteins and therapeutic and diagnostic methods for use |
摘要 |
High affinity fusion proteins ("trapbodies"), capable of binding and inhibiting the activity of soluble, interacting proteins ("SIPs") are described. The trapbodies are multimers, preferably dimers, of SIP-specific fusion polypeptides which comprise SIP binding domains derived from SIP targets and/or anti-SIP immunoglobulins, as well as multimerizing components.
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申请公布号 |
US7083950(B2) |
申请公布日期 |
2006.08.01 |
申请号 |
US20030610452 |
申请日期 |
2003.06.30 |
申请人 |
REGENERON PHARMACEUTICALS, INC. |
发明人 |
STAHL NEIL;YANCOPOULOS GEORGE D.;KAROW MARGARET |
分类号 |
C12P21/04;C07H21/04;C07K14/715;C07K16/24;C07K16/46;C12N15/62 |
主分类号 |
C12P21/04 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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