SOLID LIPID COMPOSITIONS OF LIPOPHILIC COMPOUNDS FOR ENHANCED ORAL BIOAVAILABILITY

摘要

Lipophilic substances of poor oral bioavailability are mixed with at least o ne solid fat and phospholipid to obtain a dried solid composition suitable as an oral dosage form. The solid lipid compositions ar e exemplified for food additives or dietary supplements such as Coenzyme Q10 and for pharmaceuticals such as dexanabinol. The Coenzyme Q1 0- dry lipid mixtures shows improved drug release in vitro and enhanced oral bioavailability in vivo compared to a commercial CoQ 10 formulation. The dexanabinol-dry lipid mixture similarly shows greatly enhanced oral bioavailability compared to known formulations.< /SDOAB>