Antiamyloid phenylsulfonamides: N-cycloalkylcarboxamides derivatives

摘要

A series of N-cycloalkylcarboxamide derivatives of N-benzyl benzenesulfonamides of Formula I are described. The compounds inhibit beta-amyloid peptide (beta-AP) production and are useful in the treatment of Alzheimer's Disease and other conditions characterized by aberrant extracellular deposition of beta-amyloid. Pharmaceutical compositions and methods of treatment using these compounds are also disclosed.