发明名称 |
REORIENTACAO DA IMUNIDADE CELULAR POR QUIMERAS DA CINASE DE TIROSINA DA PROTEINA |
摘要 |
Disclosed is a method of directing a cellular response in a mammal by expressing in a cell of the mammal a chimeric receptor which causes the cells to specifically recognize and destroy an infective agent, a cell infected with an infective agent, a tumor or cancerous cell, or an autoimmune-generated cell. The chimeric receptor includes an extracellular portion which is capable of specifically recognizing and binding the target cell or target infective agent, and (b) an intracellular portion of a protein-tyrosine kinase which is capable of signalling the therapeutic cell to destroy a receptor-bound target cell or a receptor-bound target infective agent. Also disclosed are cells which express the chimeric receptors and DNA encoding the chimeric receptors. |
申请公布号 |
PT812352(E) |
申请公布日期 |
2006.07.31 |
申请号 |
PT19960903666T |
申请日期 |
1996.01.24 |
申请人 |
THE GENERAL HOSPITAL CORPORATION |
发明人 |
SEED, BRIAN;CHARLES ROMEO;WALDEMAR KOLANUS |
分类号 |
C12N15/09;A61K35/12;A61K35/14;A61K38/00;A61K48/00;C07K14/705;C07K14/725;C07K14/73;C07K14/735;C07K19/00;C12N5/08;C12N5/10;C12N9/12;C12N15/62;C12N15/863;(IPC1-7):C07K14/435 |
主分类号 |
C12N15/09 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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