Diketohydrazine derivative compounds and drugs containing the compounds as the active ingredient

摘要

Diketohydrazine derivatives represented by the following general formula (I) and pharmaceutically acceptable salts thereof that have a cysteine protease inhibitory activity are disclosed wherein the variables are as defined in the specification. Because of having a cysteine protease inhibitory activity, these compounds are useful as remedies for inflammatory diseases, immune diseases, ischemic diseases, respiratory diseases, circulatory diseases, blood diseases, nerve diseases, liver/biliary duct diseases, bone/joint diseases, metabolic diseases and so on. Because of having an elastase inhibitory activity, these compounds are also useful as remedies for COPD (chronic obstructive pulmonary disease).