| 摘要 |
Co-poly(hydroxyglutamine) (A) comprising many, same or different, pendant hydrophobic groups (HG) is new. An independent claim is also included for: (1) Composition comprising (A) with pendant hydrophobic groups and at least one active agent; (2) Preparation of a composition of (A) comprising reacting poly(L-glutamic acid) (Y) with isobutyl chloroformate, and simultaneously or sequentially, reacting with a compound that introduces HG, and a compound that introduces hydroxyalkylamino. Alternatively, (Y) is reacted first with a HG-containing compound and then with isobutyl chloroformate and hydroxyalkylamine, and HG is grafted on to the hydroxy groups of a poly(alkyl-L-glutamate) alkylamide.
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