| 摘要 |
Disclosed is a method of inhibiting Cladosporium growth in an aqueous ophthalmic solution comprising a cellulose derivative and a hydrogen peroxide source, comprising: providing an aqueous solution comprising a cellulose derivative and a hydrogen peroxide source, wherein said solution will support Cladosporium growth if contaminated with Cladosporium; and admixing an effective amount of between 0.05% and 0.1% dissolved alkaline earth metal salt by weight with said solution to yield a solution which, if contaminated with Cladosporium, will allow less Cladosporium growth than an otherwise identical solution that does not comprise an alkaline earth metal salt. Further disclosed is an ophthalmic solution comprising: (a) a hydrogen peroxide source in an amount to produce trace amounts of hydrogen peroxide of less than 100 ppm (b) a cellulose derivative (c) water; and (d) an effective amount of between 0.05% and 0.1% dissolved alkaline earth metal salt by weight such that if said solution is contaminated with Cladosporium, less Cladosporium growth will occur in said solution than an otherwise identical solution that does not comprise an alkaline earth metal salt.
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