| 摘要 |
<p>Preparation of phenolic hydroxy-substituted compounds (I) comprises desalkylation of alkyl aryl ether compounds (II) with thiourea/aluminum chloride reagent pair. Preparation of phenolic hydroxy-substituted compounds of formula (I) comprises desalkylation of an alkyl aryl ether compounds of formula (II) with thiourea/aluminum chloride reagent pair. R 1>1-6C alkyl; and either R 2>-R 6>H, halo, OH, carboxy, nitro, oxo, 1-6C alkylcarbonyl, alkyl, alkoxy or aryl; or R 2>+R 3>5-7 membered ring or fused ring system (optionally substituted with an oxo or unsaturated ring; where the fused ring may constitute with the first ring to form a steroid (preferably estratriene derivative optionally substituted with oxo or 1-6C alkylcarbonyloxy group in the 17 position)). [Image].</p> |
