发明名称 |
Treatment of conditions associated with the presence of macromolecular aggregates, particularly ophthalmic disorders |
摘要 |
A method and formulation are provided for the treatment of medical conditions associated with the formation and/or deposition of macromolecular aggregates, particularly those associated with adverse ocular conditions. The formulation contains a non-cytotoxic chelating agent containing at least three negatively charged chelating atoms and a charge-masking agent containing at least one polar group and having a molecular weight of less than about 250, wherein the polar group contains at least one and preferably at least two heteroatoms having a Pauling electronegativity greater than about 3.00, and further wherein the molar ratio of the charge-masking agent to the chelating agent is sufficient to ensure that substantially all negatively charged chelating atoms are associated with a heteroatom on the charge-masking agent.
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申请公布号 |
US2006166879(A1) |
申请公布日期 |
2006.07.27 |
申请号 |
US20050182999 |
申请日期 |
2005.07.15 |
申请人 |
CHAKSHU RESEARCH INC |
发明人 |
BHUSHAN RAJIV;GIN JERRY B. |
分类号 |
A61K38/17;A61K9/00;A61K31/185;A61K38/05;A61K48/00 |
主分类号 |
A61K38/17 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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