N-[(4,5-DIPHENYL-2-THIENYL)METHYL]SULFONAMIDE DERIVATIVES, PREPARATION THEREOF AND THEIR THERAPEUTIC APPLICATION

摘要

The invention relates to compounds of formula (I) in which: X represents an -SO- or -SO<SUB>2</SUB>- group; R<SUB>1</SUB> representing: a (C<SUB>1</SUB>-C<SUB>7</SUB>) alkyl; a (C<SUB>3</SUB>-C<SUB>12</SUB>) non-aromatic carbocyclic radical; a (C<SUB>3</SUB>-C<SUB>7</SUB>) cycloalkylmethyl; an unsubstituted, mono-, di- or trisubstituted phenyl; a unsubstituted, mono-, di- or trisubstituted benzyl on the phenyl; a unsubstituted, mono-, di- or trisubstituted phenethyl on the phenyl; an unsubstituted, mono-, di- or trisubstituted naphtyl; a benzhydryl; a benzhydryl methyl, and; an aromatic heterocyclic radical, R<SUB>2</SUB> represents a hydrogen atom or a (C<SUB>1</SUB>-C<SUB>3</SUB>) alkyl group; R<SUB>3</SUB> represents an unsubstituted, mono-, di- or trisubstituted phenyl; R<SUB>4</SUB> represents an unsubstituted, mono-, di- or trisubstituted phenyl; n represents 0, 1 or 2, and; Alk represents a (C<SUB>1</SUB>-C<SUB>4</SUB>) alkyl. The invention also relates to a method for preparing the aforementioned compounds and to their therapeutic application.