BETA-PEPTIDES

摘要

ß-peptide regions of polypeptides can serve as structural mimics of a-helices in wild type proteins. Because a-helices of one protein often bind to a target protein in a biological pathway, a polypeptide that contains a helical ß-peptide region can be used to disrupt this type of protein-protein binding. As a result, polypeptides that contain a helical ß-peptide region can be used to treat conditions involving this type of protein­ protein binding, such as viral infections and cell proliferation.