| 摘要 |
This invention provides compounds of the formula: wherein: X is a chemical bond, -CH<SUB>2</SUB>- or -C(O)-; R<SUB>1 </SUB>is alkyl, cycloalkyl, -CH<SUB>2</SUB>-cycloalkyl, pyridinyl, -CH<SUB>2</SUB>-pyridinyl, phenyl or benzyl; R<SUB>2 </SUB>is H, alkyl, cycloalkyl, -CH<SUB>2</SUB>-cycloalkyl, or perfluoroalkyl; R<SUB>3 </SUB>is H, halo, alkyl, perfluoroalkyl, alkoxy, cycloalkyl, -CH<SUB>2</SUB>-cycloalkyl, -NH<SUB>2</SUB>, or -NO<SUB>2</SUB>; R<SUB>4 </SUB>is optionally substituted phenyl, benzyl, benzyloxy, pyridinyl, or -CH<SUB>2</SUB>-pyridinyl, or the salt or ester forms thereof, as well as methods for using the compounds as inhibitors of plasminogen activator inhibitor-1 (PAI-1) and as therapeutic compositions for treating conditions resulting from fibrinolytic disorders such as deep vein thrombosis and coronary heart disease, and pulmonary fibrosis.
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