NOVEL TOPICAL APPLICATION AGENTS AGAINST MIMIC AND AGE-RELATED WRINKLES

摘要

The invention relates to novel compounds of formula (I), where X = a bond or NH-CH (C=O) - (CH₂) _3+n-NH-R⁵,n = 0, 1 or 2, R¹, R⁴ and R⁵ independently = H, optionally-substituted C₆ alkyl, amidino or tetra C₁-C₆ alkylamidinium, R² = H or optionally-substituted C₁-C₆ alkyl, or R¹ and R² together with the group to which they are bonded form a 5- to 7-membered saturated ring, R³ = C₁-C₁₂ alkoxy, C₁-C₁₂ alkylamino, optionally-substituted aryl C₁-C₆ alkylamino, optionally-substituted heteroaryl C₁-C₆ alkylamino, optionally-substituted aryl C₁-C₆ alkoxy, or optionally-substituted heteroaryl C₁-C₆ alkoxy, and R⁶ = H or, when n = 1, amino, or together with R¹ and the group to which R⁶ and R¹ are bonded, a 5- to 7-membered, saturated ring and the physiologically-acceptable salts thereof. The above can be produced by conventional methods and processed to provide topical application compositions, suitable for the treatment of mimic and age-related wrinkles in human skin.