发明名称 |
GROWTH FACTOR COMPOSITION |
摘要 |
<p>A composition is provided, which is capable of generating hard tissue when introduced in a mammalian subject and comprises a) an ionic complex of i) chitosan and ii) a negatively charged polysaccharide selected from the group consisting of heparin, heparan sulfate and dextran sulfate, and b)a hard tissue generating growth factor, said ionic complex being a carrier for said hard tissue generating growth factor. Also provided are a method of preparation in vitro of a bone graft substitute using the composition, a kit for carrying out the method, as well as use of the composition in the preparation of a medical device for generation of hard tissue in a mammalian subject in need thereof, and a method of generation of hard tissue at a desired site in a mammalian subject in need thereof.</p> |
申请公布号 |
WO2006078211(A1) |
申请公布日期 |
2006.07.27 |
申请号 |
WO2006SE00077 |
申请日期 |
2006.01.19 |
申请人 |
BONOSS MEDICAL AB;ARNANDER, CLAES;ENGSTRAND, THOMAS;LARM, OLLE;VELTHEIM, RIIKKA |
发明人 |
ARNANDER, CLAES;ENGSTRAND, THOMAS;LARM, OLLE;VELTHEIM, RIIKKA |
分类号 |
A61K38/18;A61K31/715;A61K31/721;A61K31/722;A61K31/727;A61L27/26;A61P19/00 |
主分类号 |
A61K38/18 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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