| 摘要 |
<p>Pharmaceutical composition containing one or more botulinum neurotoxins (A) from Clostridium botulinum types A-G in which (A) is free of proteins that are naturally combined with (A) in complexes, is new. ACTIVITY : Antispasmodic; antimigraine. A patient, with torticollis spasmodicus had been treated with Botox (RTM for native neurotoxin-protein complexes) for 5 years and produced neutralizing antibodies, so no longer responded to treatment. He was treated with 145 units of uncomplexed (A), equivalent to the doses of Botox (RTM) previously given, and within 72 hr the muscles were relaxed, the head was held normally and muscular pain was alleviated. No adverse effects were observed. MECHANISM OF ACTION : Motor end plate nerve ending binder.</p> |
