发明名称 |
METHOD FOR ISOLATING AND PURIFYING SUBSTANCE OF TOBRAMYCIN BASE |
摘要 |
FIELD: pharmaceutical technology, antibiotics. ^ SUBSTANCE: invention relates to a method for isolation and purification of the substance tobramycin base. Method involves using the preliminary prepared cultural liquid that is subjected to the profound acid treatment and the following neutralization. Liquid is subjected for interaction with sorbent KB-2 in sorption-pulsating column fitted with KRIMZ headpieces, pulsator and air lift under the definite parameters of pulsation. Invention provides preparing the substance of tobramycin base with the low content of impurities, enhancing yield of the end product and reducing period in the process carrying out. ^ EFFECT: improved isolating and purifying method. ^ 2 cl, 1 ex |
申请公布号 |
RU2280648(C2) |
申请公布日期 |
2006.07.27 |
申请号 |
RU20000129653 |
申请日期 |
2000.11.27 |
申请人 |
TSENTR VOENNO-TEKHNICHESKIKH PROBLEM BIOLOGICHESKOJ ZASHCHITY NAUCHNO-ISSLEDOVATEL'SKOGO INSTITUTA MIKROBIOLOGII MINISTERSTVA OBORONY ROSSIJSKOJ FEDERATSII |
发明人 |
NOGOVITSYNA LJUDMILA VASIL'EVNA;MIKHAJLOV VIKTOR ALEKSANDROVICH;KHARECHKO ANATOLIJ TROFIMOVICH;SADOVOJ NIKOLAJ VASIL'EVICH |
分类号 |
C07H15/234 |
主分类号 |
C07H15/234 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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