METHODS AND COMPOSITIONS FOR USING SAX2

摘要

The present invention is generally directed to factors involved in energy metabolism. More specifically, a new gene is identified and shown to be a homeobox Sax2 gene that is involved with an obesity phenotype. Deletion of the causes growth retardation starting at birth and high postnatal lethality. Further, abrogation of the gene leads to a lack of fat accumulation in white adipose tissue and brown adipose tissue, as well as low blood glucose levels. Methods and compositions for making and using the product of the gene as well as for the manufacture of medicament for the treatment of obesity and obesity-related disorders are described.