发明名称 |
Method of inducing an enhanced immune response against hiv |
摘要 |
An efficient means of inducing an immune response against human immunodeficiency virus (HIV) utilizing specific prime-boost regimes is disclosed. The specific prime-boost regimes employ a heterologous prime-boost protocol employing recombinant adenoviral vectors of alternative and distinct serotypes comprising exogenous genetic material encoding a common HIV antigen. Vaccines administered into living vertebrate tissue in accordance with the disclosed regimes, preferably a mammalian host, such as a human or a non-human mammal of commercial or domestic veterinary importance, express the HIV-1 antigen (e.g., Gag), inducing a cellular immune response which specifically recognizes HIV-1. It is believed that the disclosed prime/boost regime will offer a prophylactic advantage to previously uninfected individuals and/or provide a therapeutic effect by reducing viral load levels within an infected individual, thus prolonging the asymptomatic phase of HIV-1 infection.
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申请公布号 |
US2006165664(A1) |
申请公布日期 |
2006.07.27 |
申请号 |
US20040507237 |
申请日期 |
2004.09.09 |
申请人 |
EMINI EMILIO A;SHIVER JOHN W;CASIMIRO DANILO R;BETT ANDREW J;LIANG XIAOPING;FU TONG-MING |
发明人 |
EMINI EMILIO A.;SHIVER JOHN W.;CASIMIRO DANILO R.;BETT ANDREW J.;LIANG XIAOPING;FU TONG-MING |
分类号 |
A61K48/00;C12N15/09;A61K35/76;A61K39/12;A61K39/21;A61K39/235;A61P31/18;C07K14/16;C12N5/10;C12N15/861 |
主分类号 |
A61K48/00 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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