发明名称 Inhibitors of serine proteases, particularly hepatitus C virus NS3-NS4 protease
摘要 The present invention relates to compounds that inhibit serine protease activity, particularly the activity of hepatitis C virus NS3-NS4A protease. As such, they act by interfering with the life cycle of the hepatitis C virus and are also useful as antiviral agents. The invention further relates to compositions comprising these compounds either for ex vivo use or for administration to a patient suffering from HCV infection. The invention also relates to methods of treating an HCV infection in a patient by administering a composition comprising a compound of this invention. The invention further relates to processes for preparing these compounds.
申请公布号 ZA200408243(B) 申请公布日期 2006.07.26
申请号 ZA20040008243 申请日期 2004.10.12
申请人 VERTEX PHARMACEUTICALS INCORPORATED 发明人 JANOS PITLIK;COTRELL, KEVIN, M.;FARMER, LUC, J.;PERNI, ROBERT, B.;COURTNEY, LAWRENCE, F.;VAN DRIE, JOHN, H.;MURCKO, MARK, A.
分类号 C12N9/99;A61K;A61K38/00;A61K38/04;A61P;A61P1/16;A61P31/12;A61P31/14;A61P37/02;A61P43/00;C07D;C07D209/42;C07D401/12;C07D403/12;C07D405/12;C07D405/14;C07D417/12;C07D471/04;C07F;C07K;C07K5/04;C07K5/06;C07K5/10;C07K7/02 主分类号 C12N9/99
代理机构 代理人
主权项
地址