发明名称 |
PHARMACOLOGICAL APPLICATIONS OF MITOCHONDRIAL DNA ASSAYS |
摘要 |
The invention provides assays to determine the relative amount of mitochondrial DNA in a subject, such as a subject undergoing drug treatment. The subject may for example be a human patient undergoing treatment for an HIV infection with a nucleic acid precursor such as a nucleoside or nucleotide analogue. The assays of the invention may include PCR assays, such semi-quantitative or quantitative PCR involving the co-amplification of a mitochondrial sequence and a reference sequence, such as a genomic sequence. Information from such assays may be evaluated to provide a ratio of mithchondrial DNA to nuclear DNA in the cells of the subject. |
申请公布号 |
EP1395681(B1) |
申请公布日期 |
2006.07.26 |
申请号 |
EP20020729732 |
申请日期 |
2002.05.29 |
申请人 |
THE UNIVERSITY OF BRITISH COLUMBIA |
发明人 |
COTE, HELENE;MONTANER, JULIO;O'SHAUGHNESSY, MICHAEL, V. |
分类号 |
C12Q1/68;G01N33/50;C12N15/09 |
主分类号 |
C12Q1/68 |
代理机构 |
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代理人 |
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地址 |
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