| 摘要 |
<p>According to the invention, a process for the preparation of a statin is provided, comprising the following steps: a) preparation of a compound of the formula II in which S<SUP>1 </SUP>denotes a hydrogen atom or a hydroxylprotective group, S<SUP>2 </SUP>and S<SUP>3</SUP>, independently of one another, denote hydroxylprotective groups and R<SUP>1 </SUP>represents a hydrogen atom or a carboxylprotective group, by stereoselective hydrogenation of a compound of the formula III to give a compound of the formula II-a and optionally introduction of a hydroxylprotective group and b) lactonization of the compound of the formula II to give a compound of the formula I-a</p> |
