发明名称 |
Macrolide-Conjugates with anti-inflammatory activity |
摘要 |
The present invention relates to new compounds represented by Formula I:
wherein M represents a macrolide subunit of the substructure II:
L represents the chain of the substructure III:
€ƒ€ƒ€ƒ€ƒ€ƒ€ƒ€ƒ€ƒ -X 1 -(CH 2 ) m -Q-(CH 2 ) n -X 2 -€ƒ€ƒ€ƒ€ƒ€ƒ III
D represents the steroid or nonsteroidal subunit derived from steroid or nonsteroidal (NSAID) drugs with anti-inflammatory activity; The present invention relates also to pharmaceutically acceptable salts and solvates of such prepared compounds, to processe and intermediates for their preparation, as well as to the improved therapeutic action and the use in the treatment of inflammatory diseases and conditions in humans and animals. |
申请公布号 |
ZA200508388(B) |
申请公布日期 |
2006.07.26 |
申请号 |
ZA20050008388 |
申请日期 |
2005.10.17 |
申请人 |
PLIVA-INSTRAZIVACKI INSTITUT D.O.O. |
发明人 |
MLADEN MERCEP;MILAN MESIC;LINDA TOMASKOVIC;STRIBOR MARKOVIC;BOSKA HIRVACIC;ORESTA MAKARUHA;VISNJA POLJAK |
分类号 |
C07D;C07D273/00;C07D413/12;C07D473/04;C07H17/08;C07J;C07J1/00 |
主分类号 |
C07D |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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