RECOMBINANT ANTIBODIES AND FRAGMENTS RECOGNISING GANGLIOSIDE N-GLYCOLYL-GM3 AND USE THEREOF IN THE DIAGNOSIS AND TREATMENT OR TUMOURS

摘要

The present invention is mainly related with the monoclonal antibody that recognizes antigens that contained the N-glycolil GM3 ganglioside and not other gangliosides of the N-glycolil or N-acetyl type, or the sulphated glycolipids. More specifically the present invention is related with the peptides sequences that codify a recombinant monoclonal antibody derived from the 14F7 antibody that recognizes the N-glycolil GM3 ganglioside, or fragments derived from it and pharmaceutical compositions containing said recombinant antibody or its fragments and its use in diagnosis or therapy of berast cancer and melanoma.