发明名称 |
Model animal with favorite onset or rheumatoid arthritis |
摘要 |
The present invention provides a model animal with favorite onset of rheumatoid arthritis wherein the severity of arthritis reaches the maximum level and its onset ratio is a hundred percent, and a screening method of a remedy for rheumatoid arthritis by using the model animal. A mouse whose function of immunoglobulin Fcgamma receptor IIB gene is deficient on its chromosome and a wild-type collagen-induced arthritis-susceptible DBA/1J mouse are backcrossed six times or more, and a model mouse with favorite onset of rheumatoid arthritis is constructed. This model mouse with favorite onset of rheumatoid arthritis is immunized with bovine joint-origin type II collagen to develop collagen-induced arthritis.
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申请公布号 |
US7081562(B1) |
申请公布日期 |
2006.07.25 |
申请号 |
US20020148413 |
申请日期 |
2002.05.29 |
申请人 |
JAPAN SCIENCE AND TECHNOLOGY AGENCY |
发明人 |
NAKAMURA AKIRA;NUKIWA TOSHIHIRO;TAKAI TOSHIYUKI |
分类号 |
A01K67/027;A61K45/00;A61P29/00;C07K14/735;C12N5/10;C12N15/00;C12N15/09;C12N15/85;G01N33/15;G01N33/50 |
主分类号 |
A01K67/027 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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