Benzyllactobionamides as inhibitors of smooth muscle cell proliferation

摘要

This invention provides smooth muscle cell proliferation inhibitors of formula I having the structure wherein R¹, R², R³, R⁴, R⁵, R⁶, R⁷, and R⁸ are each, independently, acyl of 2-7 carbon atoms, haloacyl of 2-7 carbon atoms, nitroacyl of 2-7 carbon atoms, cyanoacyl of 2-7 carbon atoms, trifluoromethylacyl of 3-8 carbon atoms, benzoyl, or -SO₃H; R⁹ is hydrogen, CN, NO₂, halo, CF₃, alkyl of 1-6 carbon atoms, or alkoxy of 1-6 carbon atoms; R¹⁰ is hydrogen, -NO₂, -NHR¹¹, -NHR¹³, -N(R¹³)₂, -NCH₃R¹³, -NHCO₂alkyl, wherein the alkyl moiety contains 1-6 carbon atoms, alkylsulfonamide of 1 to 4 carbon atoms, Z is O or S; R¹¹ is an alpha-amino acid in which the alpha carboxyl group forms an amide with the nitrogen of R¹⁰, wherein if said amino acid is glutamic acid or aspartic acid, the non-alpha carboxylic acid is an alkyl ester in which the alkyl moiety contains from 1-6 carbon atoms; R¹² is hydrogen, CN, NO₂, halo, CF₃, alkyl of 1-6 carbon atoms, alkoxy of 1-6 carbon atoms, acyl of 2-7 carbon atoms, or benzoyl; R¹³ is hydrogen, acyl of 2-7 carbon atoms, haloacyl of 2-7 carbon atoms, nitroacyl of 2-7 carbon atoms, cyanoacyl of 2-7 carbon atoms, trifluoromethylacyl of 3-8 carbon atoms, or benzoyl; or a pharmaceutically acceptable salt thereof.