| 摘要 |
The invention relates to the use of morpholino-nucleosides of formula: in which R<SUP>1 </SUP>represents a nucleic base and R<SUP>2 </SUP>represents a group corresponding to one of the following formulae: <?in-line-formulae description="In-line Formulae" end="lead"?>-(CH<SUB>2</SUB>)<SUB>n</SUB>-NH<SUB>2 </SUB>-(CH<SUB>2</SUB>)<SUB>n</SUB>-SH<?in-line-formulae description="In-line Formulae" end="tail"?> <?in-line-formulae description="In-line Formulae" end="lead"?>-(CH<SUB>2</SUB>)<SUB>n</SUB>-COOH -(CH<SUB>2</SUB>)<SUB>n</SUB>-OH<?in-line-formulae description="In-line Formulae" end="tail"?> <?in-line-formulae description="In-line Formulae" end="lead"?>-(CH<SUB>2</SUB>)<SUB>n</SUB>-NH-R<SUP>3 </SUP>-(CH<SUB>2</SUB>)<SUB>n</SUB>-SR<SUP>3</SUP><?in-line-formulae description="In-line Formulae" end="tail"?> <?in-line-formulae description="In-line Formulae" end="lead"?>-(CH<SUB>2</SUB>)<SUB>n</SUB>-CO-R<SUP>3 </SUP>-(CH<SUB>2</SUB>)<SUB>n</SUB>-OR<SUP>3</SUP><?in-line-formulae description="In-line Formulae" end="tail"?> in which n is an interger ranging from 1 to 12 and R<SUP>3 </SUP>is a group derived from a label, from a protein, from an enzyme, from a fatty acid or from a peptide, as chain terminators in a process of DNA or RNA sequencing by the Sanger method, or for the labelling of DNA or RNA fragments.
|
