| 发明名称 |
O2-substituted 1-[(2-carboxylato)pyrrolidin-1-yl]diazen-1-ium-1,2-diolates |
| 摘要 |
The present invention provides O<SUP>2</SUP>-substituted 1-[(2-carboxylato)pyrrolidin-1-yl]diazen-1-ium-1,2-diolates (1-[(2-carboxylato)pyrrolidin-1-yl]diazeniumdiolates) of the formula in which R and R<SUP>22</SUP>are as described herein. Also provided is a composition comprising such a compound and a carrier. The 1-[(2-carboxylato)pyrrolidin-1-yl]diazeniumdiolates compounds release nitric oxide under physiological conditions and are useful for treating biological disorders.
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| 申请公布号 |
US7081524(B2) |
申请公布日期 |
2006.07.25 |
| 申请号 |
US20050104232 |
申请日期 |
2005.04.12 |
| 申请人 |
THE UNITED STATES OF AMERICA AS REPRESENTED BY THE DEPARTMENT OF HEALTH AND HUMAN SERVICES |
发明人 |
SAAVEDRA JOSEPH E;KEEFER LARRY K |
| 分类号 |
C07D207/50;A61K31/655;A61K31/726;A61K31/785;A61P35/00;C07C291/08;C07D207/16;C07D213/64;C07D239/34;C07D295/28;C07H19/06;C07H19/16 |
主分类号 |
C07D207/50 |
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