The transmembrane human protein thrombomodulin (TM), as a critical regulator of the protein C pathway, represents the major anticoagulant mechanism that is operative in both normal and injured blood vessels under physiologic conditions in vivo. Compositions and methods are disclosed relating to thrombomodulin derivatives and conjugates, including methods for site-specific pegylation and compositions of a truncated thrombomodulin derivative.
申请公布号
WO2005081926(A3)
申请公布日期
2006.07.20
申请号
WO2005US05554
申请日期
2005.02.22
申请人
EMORY UNIVERSITY;CHAIKOF, ELLIOT, L.;CAZALIS, CHRYSTELLE, S.;HALLER, CAROLYN, A.
发明人
CHAIKOF, ELLIOT, L.;CAZALIS, CHRYSTELLE, S.;HALLER, CAROLYN, A.