发明名称 |
COMPOSITIONS AND METHODS FOR INCREASING THE BIOAVAILABILITY OF PULMONARILY ADMINISTERED INSULIN |
摘要 |
<p>A pharmaceutical composition suitable for pulmonary delivery includes insulin and EDTA. The presence of EDTA is effective to increase the relative pulmonary bioavailability of the insulin compared to the relative pulmonary bioavailability exhibited by a composition having the same components but absent the EDTA. The composition is in dry powder form. A method of treating or ameliorating diabetes or a related condition in a mammal includes administering by inhalation a pharmacologically effective amount of the composition. A method of improving the pulmonary bioavailability of an insulin composition includes adding EDTA to an insulin composition suitable for pulmonary delivery, wherein the composition is in dry powder form.</p> |
申请公布号 |
WO2006076277(A1) |
申请公布日期 |
2006.07.20 |
申请号 |
WO2006US00641 |
申请日期 |
2006.01.10 |
申请人 |
NEKTAR THERAPEUTICS;KOVELESKY, ROSEMARY |
发明人 |
KOVELESKY, ROSEMARY |
分类号 |
A61K38/28;A61K9/14;A61K9/19;A61K31/198;A61P5/50 |
主分类号 |
A61K38/28 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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