| 摘要 |
<p><P>PROBLEM TO BE SOLVED: To provide an animal model of saliva secretion and pancreatic secretion insufficiency useful for the development of an agent for the treatment or prevention of diseases accompanying exocrine secretion insufficiency or excessive exocrine secretion or the investigation of pathogenetic mechanism. <P>SOLUTION: The invention provides a non-human vertebrate lacking functional type 3 inositol 1,4,5-triphosphate receptor (IP<SB>3</SB>R3) and/or type 2 inositol 1,4,5-triphosphate receptor (IP<SB>3</SB>R2). <P>COPYRIGHT: (C)2006,JPO&NCIPI</p> |
