发明名称 |
VERFAHREN ZUR DETEKTION VON VITAMIN D METABOLITEN |
摘要 |
We disclose methods for measuring vitamin D metabolite in plasma or serum samples. The methods comprise a step of adding to the plasma or serum samples a non-competitive displacement agent comprising 8-anilino-1-naphthalenesulfonic acid ammonium salt, 3-(acetonylbenzyl)-4-hydroxycoumarin and a water miscible solvent. The non-competitive displacement agent separates vitamin D metabolite from binding proteins in the sample, such that the displaced vitamin D metabolite is available for capture and detection in subsequent binding assays. Thus, our invention finds use in methods of separating and detecting vitamin D metabolites otherwise tightly bound to plasma or serum binding proteins. |
申请公布号 |
DE60120487(D1) |
申请公布日期 |
2006.07.20 |
申请号 |
DE2001620487 |
申请日期 |
2001.12.06 |
申请人 |
IMMUNODIAGNOSTIC SYSTEMS LTD., BOLDON |
发明人 |
LAURIE, DAVID;BARNES, KIRKLEY;GARDNER, JAMES |
分类号 |
G01N33/48;G01N21/76;G01N21/77;G01N21/78;G01N33/53;G01N33/543;G01N33/58;G01N33/82 |
主分类号 |
G01N33/48 |
代理机构 |
|
代理人 |
|
主权项 |
|
地址 |
|